Matthias nahrendorf biography of william

We further found that after myocardial infarction, increased sympathetic nerve activity modulates the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells. Mouse Imaging. Newly produced leukocytes migrate to the atherosclerotic plaque, rendering it more inflamed and vulnerable to rupture, triggering reinfarction, a frequent clinical event that was previously unexplained.

The laboratory focuses on the role of immunity in cardiovascular disease, specifically in atherosclerosis and heart failure.

Gordon Center for Medical Imaging - Harvard University

Aguirre Lab. Sci Transl Med. In the healthy heart, cardiac resident macrophages connect to myocytes via gap junctions and participate in electric conduction; their depletion leads to conduction abnormalities such as AV block. These cells 'lose their GPS', i. Activation of hematopoiesis in cardiovascular disease. Professor of Radiology Harvard Medical School.

Matthias nahrendorf biography of william: What is he best known

We discovered that healing after myocardial infarction involves time-resolved monocyte and macrophage subset dynamics. In atherosclerosis and chronic heart failure, macrophages expand by proliferating locally, and there is interaction between local and systemic inflammation, including in the remote myocardium after ischemic injury.

Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction or stroke. Matthias Nahrendorf, M. We further found that MI, chronic stress and sedentary life style modulate the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells Nature , Nature Med , Nature Med We described that after myocardial infarction, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart Science Goodman, PhD.

Nat Neurosci. About People Publications News Meetings. Blood Adv. Of particular interest are the supply and production of leukocytes by the hematopoietic system, and the signals that regulate hematopoiesis after ischemic injuries such as myocardial infarction or stroke. My current research interests focus on imaging of molecular processes during the healing phase after myocardial infarction.

Papers Journal Covers. Contact Us. Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction Cell Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction Cell Aguirre Lab.

Infarct-induced sympathetic nervous system signaling in the bone marrow activates hematopoietic stem cells, which begin to proliferate and relocate to the spleen where they over-produce leukocytes. The Nahrendorf laboratory focuses imaging iinflammation in cardiovascular health and disease, specifically in atherosclerosis and heart failure.

These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation at a basic level while keeping a rigorous translational perspective.